CeraNews Issue 1 | 2020

Back in Focus: Biologic Reactions to Wear Debris and Corrosion Products

Portrait of Steven M. Kurtz, Ph.D.
Steven M. Kurtz, Ph.D.
Exponent, Inc., Drexel University

It is my pleasure to introduce this special issue of CeraNews, which is dedicated to the latest clinically relevant findings about particle release from orthopedic implants. This is a time-honored topic! Since the invention of THA by Charnley, there has been clinical concern about the potential for a biologic reaction to implant debris. After the introduction of modularity in the 1970s, there has also been increasing concern about fretting and corrosion products from the interfaces of modular components. The worry about wear and corrosion reignited after the recall of the ASR metal-on-metal hip in 2010.

As a result, there has been an explosion of interest in biologic reactions to metal release in the recent literature. However, there is still much to be done. This special issue of CeraNews highlights three frontier topics in clinical research for wear debris and corrosion products, including: genetic susceptibility of tissue reactions to wear debris and corrosion products; metal release in TKA; and potential systemic complications for cobalt release. Finally, although much of the focus has been on adverse tissue reactions from cobalt-chromium alloy, some implications are emerging from wear and corrosion research for ceramic components as well.

View the full editorial

FDA: Immunological response of metal containing implants under scrutiny

The US FDA calls for a common engagement involving surgeons, scientists, patients and industry to collect evidence on implant materials. The goal is to develop a better understanding of materials science and the adverse biological responses induced by some materials considered to be biocompatible and though eliciting exaggerated reactions on some patients.

Read the FDA statement on their website
Download the document “Biological Responses to Metal Implants” from the FDA website

Understand the background

ANSM: Cardiac function to be monitored in patients with metallic heads

The deposition of cobalt species in retrieved heart tissues from arthroplasty patients has been suggested to be associated with heart failures. These findings have been recently confirmed in an epidemiological study published by the French health authorities (ANSM). The ANSM recommends to monitor regularly the cardiac function in patients with metallic bearings.

Comprehend the relevance

BIOLOX®delta ceramics failed to stimulate immunological responses

With the increasing use of composite ceramic bearings in THA, a group of researchers led by Joanne Tipper investigated the biological impact of BIOLOX®delta particles. The ceramic particles failed to stimulate an inflammatory response, and did not cause any DNA damage or oxidative stress in human cells in clinically- relevant doses.

Check the evidence

CeramTec is committed to selecting and bringing to interested parties relevant articles on bioceramics related topics. The presented authors’ views and opinions are solely those of the authors of these publications. It is the focus and intent of CeraNews that CeramTec presents and comments on the authors’ views and opinions in a specific context. Such comments and editorials therefore solely express CeramTec’s views and opinions and not necessarily those of the quoted authors.

BIOLOX®delta conventional femoral heads and inserts as well as BIOLOX®OPTION are registered by CeramTec’s customers. They are not registered / available in all countries.

BIOLOX®delta, BIOLOX® and CeramTec are registered trademarks of the CeramTec Group, Germany.